Article
Phenotype and function of T cells infiltrating visceral metastases from gastrointestinal cancers and melanoma: implications for adoptive cell transfer therapy.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2013
Turcotte Simon, Gros Alena, Hogan Katherine, Tran Eric, Hinrichs Christian S, Wunderlich John R, Dudley Mark E, Rosenberg Steven A
Abstract excerpt
Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate cancer regression in patients with metastatic melanoma, but whether this approach can be applied to common epithelial malignancies remains unclear. In this study, we compared the phenotype and function of TILs derived from liver and lung metastases from patients with gastrointestinal (GI) cancers (n = 14) or melanoma (n = 42). Fewer...
Topics
- Female
- Flow Cytometry
- Gastrointestinal Neoplasms
- Humans
- Immunohistochemistry
- Immunotherapy, Adoptive
- Lymphocytes, Tumor-Infiltrating
- Male
- Melanoma
- Middle Aged