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Article

miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling.

Stem cells (Dayton, Ohio) - 1 Apr 2012

Lüningschrör Patrick, Stöcker Benedikt, Kaltschmidt Barbara, Kaltschmidt Christian

Abstract excerpt

Embryonic stem cell (ESC)-specific microRNAs (miRNAs) play a critical role in the maintenance of pluripotency and self-renewal but the complete network between these miRNAs and their broad range of target genes still remains elusive. Here we demonstrate that miR-290 cluster, the most abundant miRNA family in ESCs, targets the NF-κB subunit p65 (also known as RelA) by repressing its translation. Forced expression...

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PMID: 22232084
DOI: 10.1002/stem.1033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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