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Article

Paracrine Mechanisms Involved in the Control of Early Stages of Mammalian Spermatogenesis

1 Jan 2013

Abstract excerpt

Within the testis, Sertoli-cell is the primary target of pituitary FSH. Several growth factors have been described to be produced specifically by Sertoli cells and modulate male germ cell development through paracrine mechanisms. Some have been shown to act directly on spermatogonia such as GDNF, which acts on self-renewal of spermatogonial stem cells (SSCs) while inhibiting their differentiation; BMP4, which has...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 24324457
DOI: 10.3389/fendo.2013.00181

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