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Regulation of spermatogonial stem cell self-renewal and spermatocyte meiosis by Sertoli cell signaling

12 Dec 2014

Abstract excerpt

Spermatogenesis is a continuous and productive process supported by the self-renewal and differentiation of spermatogonial stem cells (SSCs), which arise from undifferentiated precursors known as gonocytes and are strictly controlled in a special 'niche' microenvironment in the seminiferous tubules. Sertoli cells, the only somatic cell type in the tubules, directly interact with SSCs to control their...

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PMID: 25504872
DOI: 10.1530/rep-14-0481

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