Structural dissection of vaccinia G9 identifies residues essential for membrane fusion and complex assembly.

Abstract excerpt

Vaccinia virus, a prototypical poxvirus, utilizes a unique multi-protein entry fusion complex (EFC), comprising 11 components, to mediate membrane fusion during host cell entry. Although the crystal structure of a truncated form of the G9 protein has been determined, the functional relevance of its structural features remains poorly understood. In this study, we systematically analyzed 47 G9 mutants to identify...

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