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Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains

22 Jul 2013

Abstract excerpt

Most current diagnostic tests for tuberculosis do not reveal the species or strain of pathogen causing pulmonary infection, which can lead to inappropriate treatment regimens and the spread of disease. Here, we report an assay for mycobacterial strain assignment based on genetically conserved mycobacterial sulfatases. We developed a sulfatase-activated probe,...

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PMID: 23878250
DOI: 10.1073/pnas.1222041110

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