Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2006

Mougous Joseph D, Senaratne Ryan H, Petzold Christopher J, Jain Madhulika, Lee Dong H, Schelle Michael W, Leavell Michael D, Cox Jeffery S, Leary Julie A, Riley Lee W, Bertozzi Carolyn R

Abstract excerpt

Sulfated molecules have been shown to modulate isotypic interactions between cells of metazoans and heterotypic interactions between bacterial pathogens or symbionts and their eukaryotic host cells. Mycobacterium tuberculosis, the causative agent of tuberculosis, produces sulfated molecules that have eluded functional characterization for decades. We demonstrate here that a previously uncharacterized sulfated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Bacterial
Share to Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Mycobacterium tuberculosis

Share to Sulfates

Share to Sulfotransferases

Share to Tuberculosis, Pulmonary

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 16537518
DOI: 10.1073/pnas.0510861103
PMCID: PMC1449680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.PMID 16537518Read ↗

Sulfate Metabolism in MycobacteriaSemantic proximity Read ↗

Sulfolipid-1 Biosynthesis Restricts <i>Mycobacterium tuberculosis</i> Growth in Human MacrophagesSemantic proximity Read ↗

Mycobacterium tuberculosis Small RNA MTS1338 Confers Pathogenic Properties to Non-Pathogenic Mycobacterium smegmatisSemantic proximity Read ↗

Characterization of the Molecular Interplay between Moraxella catarrhalis and Human Respiratory Tract Epithelial CellsSemantic proximity Read ↗

Bacterial immunostat: Mycobacterium tuberculosis lipids and their role in the host immune responseSemantic proximity Read ↗

Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approachSemantic proximity Read ↗

Bioinformatic analysis of sulfotransferases from an unexplored gut microbe, <i>Sutterella wadsworthensis 3_1_45B</i> : Possible roles towards detoxification via sulfation by the members of the human gut microbiomeSemantic proximity Read ↗

A Genome-Wide Screen in Macrophages Defines Host Genes Regulating the Uptake of Mycobacterium abscessusSemantic proximity Read ↗

Ebselen attenuates mycobacterial virulence through inhibition of ESX-1 secretionSemantic proximity Read ↗

Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasisSemantic proximity Read ↗

Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase.Semantic proximity Read ↗

Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.