Mechanism of HIV-1 virion entrapment by tetherin.

doi:10.1371/journal.ppat.1003483

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Article

Mechanism of HIV-1 virion entrapment by tetherin.

PLoS pathogens - 1 Jan 2013

Venkatesh Siddarth, Bieniasz Paul D

Abstract excerpt

Tetherin, an interferon-inducible membrane protein, inhibits the release of nascent enveloped viral particles from the surface of infected cells. However, the mechanisms underlying virion retention have not yet been fully delineated. Here, we employ biochemical assays and engineered tetherin proteins to demonstrate conclusively that virion tethers are composed of the tetherin protein itself, and to elucidate the...

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PMID: 23874200
DOI: 10.1371/journal.ppat.1003483
PMCID: PMC3715405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.