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Article

Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation.

The American journal of pathology - 1 Sept 2013

Gaber Naila, Gagliardi Mark, Patel Pranali, Kinnear Caroline, Zhang Cindy, Chitayat David, Shannon Patrick, Jaeggi Edgar, Tabori Uri, Keller Gordon, Mital Seema

Abstract excerpt

Hypoplastic left heart syndrome (HLHS) is a severe cardiac malformation characterized by left ventricle (LV) hypoplasia and abnormal LV perfusion and oxygenation. We studied hypoxia-associated injury in fetal HLHS and human pluripotent stem cells during cardiac differentiation to assess the effect of microenvironmental perturbations on fetal cardiac reprogramming. We studied LV myocardial samples from 32 HLHS and...

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Identifiers

PMID: 23871585
DOI: 10.1016/j.ajpath.2013.05.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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