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Article

Cardioprotective stress response in the human fetal heart.

The Journal of thoracic and cardiovascular surgery - 1 May 2005

Coles John G, Boscarino Cathy, Takahashi Mark, Grant Diane, Chang Astra, Ritter Julia, Dai Xiaojing, Du Changqing, Musso Gabriel, Yamabi Hideaki, Goncalves Jason, Kumar Ashu Sunny, Woodgett James, Lu Huanzhang, Hannigan Gregory

Abstract excerpt

OBJECTIVE: We propose that the fetal heart is highly resilient to hypoxic stress. Our objective was to elucidate the human fetal gene expression profile in response to simulated ischemia and reperfusion to identify molecular targets that account for the innate cardioprotection exhibited by the fetal phenotype. METHODS: Primary cultures of human fetal cardiac myocytes (gestational age, 15-20 weeks) were exposed to...

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Identifiers

PMID: 15867790
DOI: 10.1016/j.jtcvs.2004.11.055
PMCID: PMC5328676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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