Article
PPARγ and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Sept 2013
Martínez-Nava Gabriela A, Burguete-García Ana I, López-Carrillo Lizbeth, Hernández-Ramírez Raúl U, Madrid-Marina Vicente, Cebrián Mariano E
Abstract excerpt
CONTEXT: Breast cancer (BC) risk has been differentially associated with urinary levels of some phthalate metabolites. OBJECTIVE: To investigate whether PPARγ and PPARGC1B polymorphisms modulate these associations. MATERIALS AND METHODS: 208 BC cases were age-matched with 220 population controls. Phthalate metabolites were determined by HPLC-MS. PPARγ Pro12Ala (rs1801281) and PPARGC1B Ala203Pro (rs7732671) and...
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