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Article

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis.

PLoS pathogens - 1 Jan 2013

Carow Berit, Reuschl Ann-Kathrin, Gavier-Widén Dolores, Jenkins Brendan J, Ernst Matthias, Yoshimura Akihiko, Chambers Benedict J, Rottenberg Martin E

Abstract excerpt

Suppressor of cytokine signalling 3 (SOCS3) negatively regulates STAT3 activation in response to several cytokines such as those in the gp130-containing IL-6 receptor family. Thus, SOCS3 may play a major role in immune responses to pathogens. In the present study, the role of SOCS3 in M. tubercul...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23853585
DOI: 10.1371/journal.ppat.1003442
PMCID: PMC3701707

Genes

SOCS3
STAT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23853585-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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