Role of Siderophore Biosynthesis in Virulence of Staphylococcus aureus : Identification and Characterization of Genes Involved in Production of a Siderophore

Abstract excerpt

Molecular determinants underlying the production of siderophores in the human and animal pathogen Staphylococcus aureus and the contribution of siderophore production to the virulence of this bacterium have, until now, remained undefined. Here, we show that S. aureus strains RN6390 and Newman produce siderophore when the cells are starved for iron. We further identified and characterized a nine-gene,...

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