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MALDI imaging MS reveals candidate lipid markers of polycystic kidney disease

13 Jul 2013

Abstract excerpt

Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest that defined subsets of lipids may be useful as molecular disease markers. Whereas MALDI protein imaging mass spectrometry (IMS) has become a promising tool for...

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PMID: 23852700
DOI: 10.1194/jlr.m040014

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