[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].

Article

[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Mar 1990

Yang Y P

Abstract excerpt

In order to study the changes of phenotype and gene expression of carbamyl phosphate synthetase I (CPS 1) in preneoplastic altered liver cells in situ, serial cryostat sections of rat liver initiated by diethylnitrosamine (DENO) and promoted by phenobarbital (PB) were hybridized with 35S-GPS 1 cDNA probe by in situ hybridization, and immunohistochemical demonstration (PAP) of CPS 1 were made simultaneously. The...

Topics

Animals
Carbamoyl-Phosphate Synthase (Ammonia)
Diethylnitrosamine
Female
Gene Expression
Immunohistochemistry
Liver Neoplasms, Experimental
Male
Nucleic Acid Hybridization
Phenobarbital
Phenotype

Precancerous Conditions

Rats

Rats, Inbred F344

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