Article
Effects of torsemide on pharmacodynamics and pharmacokinetics of warfarin in humans and rats.
The Journal of pharmacy and pharmacology - 1 Aug 2013
Kim Han Oll, Lee Kyung Eun, Park Hee Yoon, Lee Na Ra, Oh Byeou Ree, Chang Byung Chul, Gwak Hye Sun
Abstract excerpt
OBJECTIVES: This study aimed to evaluate the effects of torsemide on warfarin therapy in humans and rats. METHODS: For the animal study, rats were orally dosed with warfarin (0.13 mg/kg, control group) or warfarin (0.13 mg/kg) with torsemide (2 mg/kg, low dose group and 10 mg/kg, high dose group)...
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