Article
[Can acute renal insufficiency increase the effect of warfarin?].
Ugeskrift for laeger - 16 Mar 2009
Arnason Bjarni, Matthisson Jakob, Madsen Hanne
Abstract excerpt
The use of warfarin is complicated by its narrow therapeutic index. The risk of severe complications in the form of haemorrhage is significantly increased by an elevated degree of anticoagulation. We present a case in which a patient in stable warfarin treatment was admitted with acute renal failure and extremely high international normalized ratio (INR). No single mechanism can fully explain this. We find that...
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