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Article

Epidemiology: clues to the pathogenesis of Burkitt lymphoma

20 Jan 2012

Abstract excerpt

The two major epidemiological clues to the pathogenesis of Burkitt lymphoma (BL) are the geographical association with malaria--BL incidence relates to the malaria transmission rate--and early infection by Epstein-Barr virus (EBV). Both agents cause B cell hyperplasia, which is almost certainly an essential component of lymphomagenesis in BL. The critical event in lymphomagenesis is the creation of a MYC...

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PMID: 22260300
DOI: 10.1111/j.1365-2141.2011.09013.x

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