Article
MiST: a new approach to variant detection in deep sequencing datasets.
Nucleic acids research - 1 Sept 2013
Subramanian Sailakshmi, Di Pierro Valentina, Shah Hardik, Jayaprakash Anitha D, Weisberger Ian, Shim Jaehee, George Ajish, Gelb Bruce D, Sachidanandam Ravi
Abstract excerpt
MiST is a novel approach to variant calling from deep sequencing data, using the inverted mapping approach developed for Geoseq. Reads that can map to a targeted exonic region are identified using exact matches to tiles from the region. The reads are then aligned to the targets to discover variants. MiST carefully handles paralogous reads that map ambiguously to the genome and clonal reads arising from PCR bias,...
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