Article
Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.
Cancer cell - 16 Aug 2011
McEvoy Justina, Flores-Otero Jacqueline, Zhang Jiakun, Nemeth Katie, Brennan Rachel, Bradley Cori, Krafcik Fred, Rodriguez-Galindo Carlos, Wilson Matthew, Xiong Shunbin, Lozano Guillermina, Sage Julien, Fu Ligia, Louhibi Lotfi, Trimarchi Jeff, Pani Amar, Smeyne Richard, Johnson Dianna, Dyer Michael A
Abstract excerpt
It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been debated for over a century. Here, we report that human and mouse retinoblastomas have molecular, cellular, and neurochemical features of multiple cell classes, principally amacrine/horizontal interneurons, retinal...
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