Article
Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.
Science translational medicine - 3 Jul 2013
Karlsson Elinor K, Harris Jason B, Tabrizi Shervin, Rahman Atiqur, Shlyakhter Ilya, Patterson Nick, O'Dushlaine Colm, Schaffner Stephen F, Gupta Sameer, Chowdhury Fahima, Sheikh Alaullah, Shin Ok Sarah, Ellis Crystal, Becker Christine E, Stuart Lynda M, Calderwood Stephen B, Ryan Edward T, Qadri Firdausi, Sabeti Pardis C, Larocque Regina C
Abstract excerpt
As an ancient disease with high fatality, cholera has likely exerted strong selective pressure on affected human populations. We performed a genome-wide study of natural selection in a population from the Ganges River Delta, the historic geographic epicenter of cholera. We identified 305 candidate selected regions using the composite of multiple signals (CMS) method. The regions were enriched for potassium...
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