Article
Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity.
Nature communications - 23 Sept 2024
Maciel-Guerra Alexandre, Babaarslan Kubra, Baker Michelle, Rahman Aura, Hossain Maqsud, Sadique Abdus, Alam Jahidul, Uzzaman Salim, Ferdous Rahman Sarker Mohammad, Sultana Nasrin, Islam Khan Ashraful, Ara Begum Yasmin, Hassan Afrad Mokibul, Senin Nicola, Hossain Habib Zakir, Shirin Tahmina, Qadri Firdausi, Dottorini Tania
Abstract excerpt
In Bangladesh, Vibrio cholerae lineages are undergoing genomic evolution, with increased virulence and spreading ability. However, our understanding of the genomic determinants influencing lineage transmission and disease severity remains incomplete. Here, we developed a computational framework using machine-learning, genome scale metabolic modelling (GSSM) and 3D structural analysis, to identify V. cholerae...
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