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Proteasome degradation of protein C and plasmin inhibitor mutants.

Thrombosis and haemostasis - 1 Sept 2008

Nishio Miwako, Koyama Takatoshi, Nakahara Masako, Egawa Nagisa, Hirosawa Shinsaku

Abstract excerpt

Protein C (PC) deficiency and plasmin inhibitor (PI) deficiency are inherited thrombotic and haemorrhagic disorders. We investigated the intracellular degradation of mutant proteins, using naturally occurring PC and PI mutants that lead to congenital deficiencies. To examine the necessity of N-linked glycosylation for the proteasomal degradation of PC and PI, PC178 and PC331 mutants treated with tunicamycin and...

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PMID: 18766255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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