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Article

Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner

25 Jun 2013

Abstract excerpt

Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical outcome remain controversial. It is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrCa or impacts BrCa progression. We are unique in reporting that asTF, but not flTF, strongly associates with both tumor size and...

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PMID: 23801760
DOI: 10.1073/pnas.1307100110

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