Article
Characterization of different osteosarcoma phenotypes by PET imaging in preclinical animal models.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Aug 2013
Campanile Carmen, Arlt Matthias J E, Krämer Stefanie D, Honer Michael, Gvozdenovic Ana, Brennecke Patrick, Fischer Cindy R, Sabile Adam A, Müller Adrienne, Ametamey Simon M, Born Walter, Schibli Roger, Fuchs Bruno
Abstract excerpt
UNLABELLED: The aim of this study was to characterize the different phenotypes of osteosarcoma by PET, comparing the uptake of 3 tracers ((18)F-FDG, (18)F-fluoromisonidazole [(18)F-FMISO], and (18)F-fluoride) in preclinical mouse models that reflect the heterogeneity of the human disease. METHODS: Mouse LM8 osteosarcoma, human 143B, and Caprin-1 stably overexpressing SaOS-2 cells were injected intratibially in...
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