Article
A new experimental rat model of osteosarcoma established by intrafemoral tumor cell inoculation, useful for biology and therapy investigations.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2000
Cherrier B, Gouin F, Heymann M-F, Thiéry J P, Rédini F, Heymann D, Duteille F
Abstract excerpt
Satisfactory experimental models for preclinical cancer studies must follow several criteria: (1) reproducibility of the method used to induce the tumor and (2) clinical, pathological and kinetic similarity with the corresponding human tumors. We developed a model of osteosarcoma locally induced by the intrafemoral injection of osteosarcoma (OSR) cells in Sprague-Dawley rats. This method yields nearly 80% of bone...
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