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Article

Aptamer Identification of Brain Tumor–Initiating Cells

24 Jun 2013

Abstract excerpt

Glioblastomas display cellular hierarchies with self-renewing tumor-initiating cells (TIC), also known as cancer stem cells, at the apex. Although the TIC hypothesis remains controversial and the functional assays to define the TIC phenotype are evolving, we and others have shown that TICs may contribute to therapeutic resistance, tumor spread, and angiogenesis. The identification of TICs has been informed by the...

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PMID: 23796560
DOI: 10.1158/0008-5472.can-12-4556

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