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Article

Rapid prenatal diagnosis of common beta-thalassemia mutations in Southeast Asia using pyrosequencing.

Prenatal diagnosis - 1 Nov 2013

Ho Sherry Sze Yee, Huan Pei Tee, Leow Gek Har, Ching Leng Kee, Chiu Lily, Law Hai Yang, Koay Evelyn S C

Abstract excerpt

OBJECTIVE: Current methods of prenatal diagnosis to detect beta-thalassemia are Sanger sequencing and reverse dot blot. These methods are time-consuming and can prolong assay turnaround time. We aim to develop a sensitive and rapid method to detect 27 beta-thalassemia mutations using pyrosequencing. METHOD: Pyrosequencing primer pairs and sequencing primers were designed to detect 27 most common beta-thalassemia...

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Source

Identifiers

PMID: 23794144
DOI: 10.1002/pd.4183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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