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Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.

Human genetics - 1 Nov 2016

Wu Sijie, Tan Jingze, Yang Yajun, Peng Qianqian, Zhang Manfei, Li Jinxi, Lu Dongsheng, Liu Yu, Lou Haiyi, Feng Qidi, Lu Yan, Guan Yaqun, Zhang Zhaoxia, Jiao Yi, Sabeti Pardis, Krutmann Jean, Tang Kun, Jin Li, Xu Shuhua, Wang Sijia

Abstract excerpt

Hair straightness/curliness is one of the most conspicuous features of human variation and is particularly diverse among populations. A recent genome-wide scan found common variants in the Trichohyalin (TCHH) gene that are associated with hair straightness in Europeans, but different genes might affect this phenotype in other populations. By sampling 2899 Han Chinese, we performed the first genome-wide scan of...

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Source

Identifiers

PMID: 27487801
DOI: 10.1007/s00439-016-1718-y

Genes

EDAR
TCHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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