Article
The imbalance between proliferation and apoptosis contributes to degeneration of aortic valves and bioprostheses.
Cardiology journal - 1 Jan 2013
Tuleta Izabela, Al Ghaddioui Abdel Karim, Bauriedel Gerhard, Wernert Nicolas, Preusse Claus Jürgen, Welz Armin, Nickenig Georg, Skowasch Dirk
Abstract excerpt
BACKGROUND: The pathomechanisms underlying aortic valve degeneration are incompletely understood. Therefore, the aim of our work was to assess the quantitative changes of proliferation and apoptosis accompanied by cellular phenotype alternations and matrix secretionin aortic sclerotic and stenotic valves and degenerative bioprostheses, as well as to detect the expression pattern of the rapamycin receptor FKBP12...
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