Article
Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).
PloS one - 1 Jan 2013
Martin Benedicte, Chesnel Franck, Delcros Jean-Guy, Jouan Florence, Couturier Anne, Dugay Frederic, Le Goff Xavier, Patard Jean-Jacques, Fergelot Patricia, Vigneau Cecile, Rioux-Leclerq Nathalie, Arlot-Bonnemains Yannick
Abstract excerpt
Clear cell renal cell carcinoma (ccRCC) is the most common histological subtype of kidney cancer and is often characterized by mutations or deletions of the Von Hippel Lindau (VHL) tumour suppressor gene. Aurora gene family members are implicated in proper mitotic progression and spindle checkpoint function and play a crucial role in cancer progression. In the present study, we assessed the expression of Aurora-A...
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