Article
Friedreich ataxia in Italian families: genetic homogeneity and linkage disequilibrium with the marker loci D9S5 and D9S15.
American journal of human genetics - 1 Aug 1990
Pandolfo M, Sirugo G, Antonelli A, Weitnauer L, Ferretti L, Leone M, Dones I, Cerino A, Fujita R, Hanauer A
Abstract excerpt
Friedreich ataxia (FA) is an autosomal recessive degenerative disease of the nervous system of unknown biochemical cause. The FA gene has been shown to be in close linkage with the two chromosome 9 markers D9S5 and D9S15, and linkage disequilibrium between FA and D9S15 has been detected in French...
Topics
- Alleles
- Blotting, Southern
- DNA Probes
- Friedreich Ataxia
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Haplotypes
- Humans
- Italy