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Article

Jagged1 immobilization to an osteoconductive polymer activates the Notch signaling pathway and induces osteogenesis.

Journal of biomedical materials research. Part A - 1 May 2014

Dishowitz Michael I, Zhu Fengchang, Sundararaghavan Harini G, Ifkovits Jamie L, Burdick Jason A, Hankenson Kurt D

Abstract excerpt

Treatment of nonunion fractures is a significant problem. Common therapeutics, including autologous bone grafts and bone morphogenetic proteins, show well-established limitations. Therefore, a need persists for the identification of novel clinical therapies to promote healing. The Notch signaling pathway regulates bone development. Clinically, loss-of-function mutations to the Notch ligand Jagged1 decrease bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23775982
DOI: 10.1002/jbm.a.34825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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