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Article

Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2).

The Journal of biological chemistry - 26 Jul 2013

Perzlmaier Angelika F, Richter Frank, Seufert Wolfgang

Abstract excerpt

The eukaryotic translation initiation factor 2 (eIF2) is central to the onset of protein synthesis and its modulation in response to physiological demands. eIF2, a heterotrimeric G-protein, is activated by guanine nucleotide exchange to deliver the initiator methionyl-tRNA to the ribosome. Here we report that assembly of the eIF2 complex in vivo depends on Cdc123, a cell proliferation protein conserved among...

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Identifiers

PMID: 23775072
DOI: 10.1074/jbc.M113.472290
PMCID: PMC3724614

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Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2).PMID 23775072Read ↗

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