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Mycobacterium tuberculosis isolates from Rio de Janeiro reveal unusually low correlation between pyrazinamide resistance and mutations in the pncA gene.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2013

Bhuju Sabin, Fonseca Leila de Souza, Marsico Anna Grazia, de Oliveira Vieira Gisele Betzler, Sobral Luciana Fonseca, Stehr Matthias, Singh Mahavir, Saad Maria Helena Féres

Abstract excerpt

It has been widely accepted, that pyrazinamide (PZA) resistance in Mycobacterium tuberculosis is correlated with mutations in the pncA gene. But since years researchers have been puzzled by the fact that up to 30% of PZA resistant strains do not show any correlation between PZA resistance and mut...

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Identifiers

PMID: 23770140
DOI: 10.1016/j.meegid.2013.06.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23770140-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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