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Article

Glutathione imbalance in patients with X-linked adrenoleukodystrophy.

Molecular genetics and metabolism - 1 Aug 2013

Petrillo Sara, Piemonte Fiorella, Pastore Anna, Tozzi Giulia, Aiello Chiara, Pujol Aurora, Cappa Marco, Bertini Enrico

Abstract excerpt

BACKGROUND: X-linked adrenoleukodystrophy (X-ALD) is a genetic disorder of X-linked inheritance caused by a mutation in the ABCD1 gene which determines an accumulation of long-chain fatty acids in plasma and tissues. Recent evidence shows that oxidative stress may be a hallmark in the pathogenesis of X-ALD and glutathione plays an important role in the defense against free radicals. In this study we have analyzed...

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Source

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Identifiers

PMID: 23768953
DOI: 10.1016/j.ymgme.2013.05.009
PMCID: PMC3732387

Genes

ABCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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