Article
Impact of single nucleotide polymorphisms on severe hepatotoxicity induced by EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring EGFR mutations.
Lung cancer (Amsterdam, Netherlands) - 1 Nov 2015
Sugiyama Eri, Umemura Shigeki, Nomura Shogo, Kirita Keisuke, Matsumoto Shingo, Yoh Kiyotaka, Niho Seiji, Ohmatsu Hironobu, Tsuboi Masahiro, Ohe Yuichiro, Goto Koichi
Abstract excerpt
BACKGROUND: Many patients are forced to discontinue treatment with EGFR tyrosine kinase inhibitors (TKIs), particularly gefitinib, due to severe hepatotoxicity. Here, we investigated the association between the rate of severe hepatotoxicity and single nucleotide polymorphisms (SNPs) in metabolic enzymes. MATERIALS AND METHODS: Multi-SNP analyses were performed in 60 patients with EGFR-mutated non-small cell lung...
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