Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.

PloS one - 1 Jan 2013

Coni Sonia, Antonucci Laura, D'Amico Davide, Di Magno Laura, Infante Paola, De Smaele Enrico, Giannini Giuseppe, Di Marcotullio Lucia, Screpanti Isabella, Gulino Alberto, Canettieri Gianluca

Abstract excerpt

The morphogenic Hedgehog (Hh) signaling regulates postnatal cerebellar development and its aberrant activation leads to medulloblastoma. The transcription factors Gli1 and Gli2 are the activators of Hh pathway and their function is finely controlled by different covalent modifications, such as ph...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellum
Share to Hedgehog Proteins
Share to Immune Sera

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to NIH 3T3 Cells

Share to p300-CBP Transcription Factors

Share to Zinc Finger Protein GLI1

Share to Zinc Finger Protein Gli2

Source

Open in PubMed Open full text

Identifiers

PMID: 23762415
DOI: 10.1371/journal.pone.0065718
PMCID: PMC3675076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23762415-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy.PMID 23762415Read ↗

Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.Semantic proximity Read ↗

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development.Semantic proximity Read ↗

Functional regulation of GATA-2 by acetylation.Semantic proximity Read ↗

Gli proteins encode context-dependent positive and negative functions: implications for development and diseaseSemantic proximity Read ↗

Nap1l2 promotes histone acetylation activity during neuronal differentiation.Semantic proximity Read ↗

Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation.Semantic proximity Read ↗

A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.Semantic proximity Read ↗

Interferon regulatory factor-2 regulates cell growth through its acetylation.Semantic proximity Read ↗

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.Semantic proximity Read ↗

Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.