Article
Using peripheral blood circulating DNAs to detect CpG global methylation status and genetic mutations in patients with myelodysplastic syndrome.
Biochemical and biophysical research communications - 23 Mar 2012
Iriyama Chisako, Tomita Akihiro, Hoshino Hideaki, Adachi-Shirahata Mizuho, Furukawa-Hibi Yoko, Yamada Kiyofumi, Kiyoi Hitoshi, Naoe Tomoki
Abstract excerpt
Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder. Several genetic/epigenetic abnormalities are deeply associated with the pathogenesis of MDS. Although bone marrow (BM) aspiration is a common strategy to obtain MDS cells for evaluating their genetic/epigenetic abnormalities, BM aspiration is difficult to perform repeatedly to obtain serial samples because of pain and safety concerns. Here, we...
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