Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression

1 Jul 2013

Abstract excerpt

Dexamethasone is a key front-line chemotherapeutic for B-cell malignant multiple myeloma (MM). Dexamethasone modulates MM cell survival signaling but fails to induce marked cytotoxicity when used as a monotherapy. We demonstrate here the mechanism behind this insufficient responsiveness of MM cells toward dexamethasone, revealing in MM a dramatic anti-apoptotic role for microRNA (miRNA)-125b in the insensitivity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to MicroRNA in disease regulation
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23759586
DOI: 10.4161/cc.25251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expressionPMID 23759586Read ↗

SUMOylation inhibition enhances dexamethasone sensitivity in multiple myelomaSemantic proximity Read ↗

SUMOylation Inhibition Enhances Dexamethasone Sensitivity in Multiple MyelomaSemantic proximity Read ↗

Dexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myelomaSemantic proximity Read ↗

Targeting the miR-221–222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple MyelomaSemantic proximity Read ↗

A p53‐Dependent Tumor Suppressor Network Is Induced by Selective miR‐125a‐5p Inhibition in Multiple Myeloma CellsSemantic proximity Read ↗

Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R CellsSemantic proximity Read ↗

LncRNA NEAT1 promotes dexamethasone resistance in multiple myeloma by targeting miR-193a/MCL1 pathway.Semantic proximity Read ↗

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma.Semantic proximity Read ↗

miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 PathwaySemantic proximity Read ↗

Downregulation of microRNA‑25‑3p inhibits the proliferation and promotes the apoptosis of multiple myeloma cells via targeting the PTEN/PI3K/AKT signaling pathwaySemantic proximity Read ↗

Frequent methylation of the tumour suppressor miR‐1258 targeting PDL1: implication in multiple myeloma‐specific cytotoxicity and prognostificationSemantic proximity Read ↗

Crosstalk between the glucocorticoid and mineralocorticoid receptor boosts glucocorticoid-induced killing of multiple myeloma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.