Article
The new sequencer on the block: comparison of Life Technology's Proton sequencer to an Illumina HiSeq for whole-exome sequencing.
Human genetics - 1 Oct 2013
Boland Joseph F, Chung Charles C, Roberson David, Mitchell Jason, Zhang Xijun, Im Kate M, He Ji, Chanock Stephen J, Yeager Meredith, Dean Michael
Abstract excerpt
We assessed the performance of the new Life Technologies Proton sequencer by comparing whole-exome sequence data in a Centre d'Etude du Polymorphisme Humain trio (family 1463) to the Illumina HiSeq instrument. To simulate a typical user's results, we utilized the standard capture, alignment and variant calling methods specific to each platform. We restricted data analysis to include the capture region common to...
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