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Article

Comparison of sequencing platforms for single nucleotide variant calls in a human sample.

PloS one - 1 Jan 2013

Ratan Aakrosh, Miller Webb, Guillory Joseph, Stinson Jeremy, Seshagiri Somasekar, Schuster Stephan C

Abstract excerpt

Next-generation sequencings platforms coupled with advanced bioinformatic tools enable re-sequencing of the human genome at high-speed and large cost savings. We compare sequencing platforms from Roche/454(GS FLX), Illumina/HiSeq (HiSeq 2000), and Life Technologies/SOLiD (SOLiD 3 ECC) for their ability to identify single nucleotide substitutions in whole genome sequences from the same human sample. We report on...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23405114
DOI: 10.1371/journal.pone.0055089
PMCID: PMC3566181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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