Article
Functional evaluation of circulating hematopoietic progenitors in Noonan syndrome.
Oncology reports - 1 Aug 2013
Timeus Fabio, Crescenzio Nicoletta, Baldassarre Giuseppina, Doria Alessandra, Vallero Stefano, Foglia Luiselda, Pagliano Sara, Rossi Cesare, Silengo Margherita Cirillo, Ramenghi Ugo, Fagioli Franca, Cordero di Montezemolo Luca, Ferrero Giovanni Battista
Abstract excerpt
Noonan syndrome (NS) is an autosomal dominant disorder, characterized by short stature, multiple dysmorphisms and congenital heart defects. A myeloproliferative disorder (NS/MPD), resembling juvenile myelomonocytic leukemia (JMML), is occasionally diagnosed in infants with NS. In the present study, we performed a functional evaluation of the circulating hematopoietic progenitors in a series of NS, NS/MPD and JMML...
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