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Article

Sequence-specific modification of genomic DNA by small DNA fragments

1 Sept 2003

Abstract excerpt

Small DNA fragments have been used to modify endogenous genomic DNA in both human and mouse cells. This strategy for sequence-specific modification or genomic editing, known as small-fragment homologous replacement (SFHR), has yet to be characterized in terms of its underlying mechanisms. Genotypic and phenotypic analyses following SFHR have shown specific modification of disease-causing genetic loci associated...

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PMID: 12952908
DOI: 10.1172/jci19773

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