A functional BRCA1 coding sequence genetic variant contributes to risk of esophageal squamous cell carcinoma.

doi:10.1093/carcin/bgt213

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A functional BRCA1 coding sequence genetic variant contributes to risk of esophageal squamous cell carcinoma.

Carcinogenesis - 1 Oct 2013

Zhang Xiaojiao, Wei Jinyu, Zhou Liqing, Zhou Changchun, Shi Juan, Yuan Qipeng, Yang Ming, Lin Dongxin

Abstract excerpt

As a tumor suppressor, breast cancer susceptibility gene 1 (BRCA1) plays a pivotal role in maintaining genomic stability. A functional rs799917 T>C polymorphism located in the BRCA1 coding sequence could influence miR-638-mediated regulation of BRCA1 expression. Therefore, we examined the association between this polymorphism and esophageal squamous cell carcinoma (ESCC) risk as well as its biological function....

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PMID: 23749772
DOI: 10.1093/carcin/bgt213

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BRCA1

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