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Poly(ADP-ribose) polymerase inhibitors as cancer therapy

1 Jan 2013

Abstract excerpt

Poly(ADP-ribose) polymerase (PARP) inhibitors are pharmacologic agents which primarily inhibit the PARP-1 and PARP-2 enzymes within the cell. Inhibition of PARP results in failure of base-excision repair (BER) to correct single-stranded breaks in DNA. This failure results in double-stranded breaks that are subsequently repaired either by homologous recombination (HR) repair, which is error-free, or by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23747892
DOI: 10.2741/4188

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