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Poly (ADP-Ribose) Polymerase as a Novel Therapeutic Target in Cancer

8 Sept 2010

Abstract excerpt

Cancer chemotherapy exploits limitations in repairing DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Poly (ADP-ribose) polymerase (PARP) and BRCA proteins are central to the repair...

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PMID: 20823142
DOI: 10.1158/1078-0432.ccr-10-0526

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