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Article

PARP inhibitors: its role in treatment of cancer.

Chinese journal of cancer - 1 Jul 2011

Chen Alice

Abstract excerpt

PARP is an important protein in DNA repair pathways especially the base excision repair (BER). BER is involved in DNA repair of single strand breaks (SSBs). If BER is impaired, inhibiting poly(ADP-ribose) polymerase (PARP), SSBs accumulate and become double stand breaks (DSBs). The cells with increasing number of DSBs become more dependent on other repair pathways, mainly the homologous recombination (HR) and the...

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Source

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Identifiers

PMID: 21718592
DOI: 10.5732/cjc.011.10111
PMCID: PMC4013421

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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