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Article

Poly-ADP-ribose polymerases (PARPs) as a therapeutic target in the treatment of selected cancers

9 Aug 2019

Abstract excerpt

Introduction: The implementation of poly-ADP-ribose polymerase (PARP) inhibitors for therapy has created potential treatments for a wide spectrum of malignancies involving DNA damage repair gene abnormalities. PARPs are a group of enzymes that are responsible for detecting and repairing DNA damage and therefore play a key role in maintaining cell function and integrity. PARP inhibitors are drugs that target DNA...

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PMID: 31394942
DOI: 10.1080/14728222.2019.1654458

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