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Article

Oxidative DNA damage in Barrett mucosa: correlation with telomeric dysfunction and p53 mutation.

Annals of surgical oncology - 1 Dec 2013

Cardin Romilda, Piciocchi Marika, Tieppo Chiara, Maddalo Gemma, Zaninotto Giovanni, Mescoli Claudia, Rugge Massimo, Farinati Fabio

Abstract excerpt

BACKGROUND: Barrett esophagus develops in a scenario of chronic inflammation, linked to free radical formation and oxidative DNA damage. Eight-hydroxydeoxyguanosine, the main oxidative DNA adduct, is partially repaired by a glycosylase (OGG1) whose polymorphism is associated to a reduced repair capacity. Telomeres are particularly prone to oxidative damage, which leads to shortening and cell senescence, while...

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Identifiers

PMID: 23744553
DOI: 10.1245/s10434-013-3043-1

Genes

OGG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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